Fatouros.Vitamin E effects on indexes of lipid peroxidation in muscle from DHEA-treated and exercised rats

Fatouros. Vitamin E effects on indexes of lipid peroxidation in muscle from DHEA-treated and exercised rats. J. Appl. Phys-iol. 76(4): 1630-1635, 1994.-Sixty-four male Sprague-Dawley rats were randomly assigned to one of eight treatment groups to determine the effects of vitamin E (VitE), dehydroepian-drosterone (DHEA), and exercise on antioxidant status in plasma and skeletal muscle. Indexes of oxidative stress were determined by measuring two markers of lipid peroxidation and the activity of two free radical scavenging enzymes. One-half of the rats-had their diets supplemented with 250 IU VitE/ kg of diet. One-half of the rats were injected with 0.35 mol/kg body wt ip of DHEA-acetate, whereas the others were injected with vehicle. All treatments lasted 5 wk. Before being killed, one-half of each treatment group of rats was randomly as-signed to run for 1 h on a motorized rodent treadmill at 2