Subpopulations of Human T-Lymphocytes. XIX. T-Cells and T-Cells With Receptors for IgMFc (Tp), IgGFc (Ty), or IgAFc (Ta) in the Peripheral Blood and Regional Lymph Nodes of Patients With Untreated Breast Cancer 1,2,3

ABSTRACT-Peripheral blood and regional lymph node mononuclear cells from 43 untreated patients with breast cancer were analyzed for the proportions of total T-cells and T-cells with receptors for the Fc portion of IgM (Til), IgG (Ty), or IgA (Ta). Proportions of total T-cells and Til cells both in peripheral blood and lymph nodes from breast cancer patients were comparable to those from health controls. The proportion of Ty cells, however, was significantly (P<O.01) increased in the peripheral blood and lymph nodes from breast cancer patients as compared to that from controls. The proportion of Ta in the periph-eral blood was comparable; however, when compared to the number of Ta cells in control lymph nodes, To cells were increased (P<O.025) in the regional lymph nodes from patients with breast cancer. When data on the proportions of T-cells and T-cell subsets were analyzed according to the presence or absence of metastatic disease in the regional lymph nodes, the proportion of Ty cells was significantl