Brown adipose tissue (BAT) and white adipose tissue (WAT) and adipocytes are targets of Trypanosoma cruzi infection. Adipose tissue obtained from CD-1 mice 15 days after infection, an early stage of infection revealed a high parasite load. There was a significant increase in macrophages in infected adipose tissue and a reduction in lipid accumulation, adipocyte size, and fat mass and increased expression of lipolytic enzymes. Infection increased levels of Toll-like receptor (TLR) 4 and TLR9 and in the expression of components of the mitogen-activated protein kinase pathway. Protein and messenger RNA (mRNA) levels of peroxisome proliferator-activated receptor g were increased in WAT, whereas protein and mRNA levels of adiponectin were signif...
<div><p>Background</p><p>The immune mechanisms underlying experimental non-alcoholic steatohepatitis...
African trypanosomiasis is a vector-borne disease caused by extracellular protozoan parasites, inclu...
Trypanosoma brucei is an extracellular parasite that causes sleeping sickness. In mammalian hosts, t...
Adipose tissue is a target of Trypanosoma cruzi infection being a parasite reservoir during the chro...
Trypanosoma cruzi infection of the adipose tissue of mice triggers the local expression of inflamm...
Background: Trypanosoma cruzi, the causative agent of Chagas disease, has high affinity for lipoprot...
Chronic Chagas cardiomyopathy (CCC) caused by a parasite Trypanosoma cruzi is a life-threatening dis...
<div><p>Background</p><p><i>Trypanosoma cruzi</i>, the causative agent of Chagas disease, has high a...
Upon infection by Trypanosoma cruzi, adipocytes adopt a clearly defined inflammatory phenotype with ...
The high fat diet (HFD) can trigger metabolic and cardiovascular diseases. Trypanosoma cruzi infecti...
Trypanosoma brucei causes African trypanosomiasis, colonizing adipose tissue and inducing weight los...
The protozoan Trypanosoma cruzi is responsible for triggering a damage immune response in the host c...
<div><p>Background</p><p>Chagas disease, caused by the protozoan <i>Trypanosoma cruzi</i> (<i>T</i>....
SummaryTrypanosoma brucei is an extracellular parasite that causes sleeping sickness. In mammalian h...
In the skin, Trypanosoma brucei colonises the subcutaneous white adipose tissue, and is proposed to ...
<div><p>Background</p><p>The immune mechanisms underlying experimental non-alcoholic steatohepatitis...
African trypanosomiasis is a vector-borne disease caused by extracellular protozoan parasites, inclu...
Trypanosoma brucei is an extracellular parasite that causes sleeping sickness. In mammalian hosts, t...
Adipose tissue is a target of Trypanosoma cruzi infection being a parasite reservoir during the chro...
Trypanosoma cruzi infection of the adipose tissue of mice triggers the local expression of inflamm...
Background: Trypanosoma cruzi, the causative agent of Chagas disease, has high affinity for lipoprot...
Chronic Chagas cardiomyopathy (CCC) caused by a parasite Trypanosoma cruzi is a life-threatening dis...
<div><p>Background</p><p><i>Trypanosoma cruzi</i>, the causative agent of Chagas disease, has high a...
Upon infection by Trypanosoma cruzi, adipocytes adopt a clearly defined inflammatory phenotype with ...
The high fat diet (HFD) can trigger metabolic and cardiovascular diseases. Trypanosoma cruzi infecti...
Trypanosoma brucei causes African trypanosomiasis, colonizing adipose tissue and inducing weight los...
The protozoan Trypanosoma cruzi is responsible for triggering a damage immune response in the host c...
<div><p>Background</p><p>Chagas disease, caused by the protozoan <i>Trypanosoma cruzi</i> (<i>T</i>....
SummaryTrypanosoma brucei is an extracellular parasite that causes sleeping sickness. In mammalian h...
In the skin, Trypanosoma brucei colonises the subcutaneous white adipose tissue, and is proposed to ...
<div><p>Background</p><p>The immune mechanisms underlying experimental non-alcoholic steatohepatitis...
African trypanosomiasis is a vector-borne disease caused by extracellular protozoan parasites, inclu...
Trypanosoma brucei is an extracellular parasite that causes sleeping sickness. In mammalian hosts, t...