Add to ORKGLoss of FMR1 gene function results in fragile X syndrome (FXS), the most common heritable form of intellectual disability. The protein encoded from this locus (FMRP) is an RNA binding protein thought to primarily act as a translational regulator, however recent studies implicate FMRP in other mechanisms of gene regulation. Here, we demonstrate that the Drosophila fragile X homolog (dFMR1) biochemically interacts with the A-to-I RNA editing enzyme, dADAR. We found that dAdar and dfmr1 mutant larvae exhibit distinct morphological neuromuscular junction (NMJ) defects. Epistasis experiments based on these phenotypic differences suggest that dAdar acts downstream of dfmr1 and that dFMR1 modulates dADAR activity. Furthermore, sequence analyses re...
RNA metabolism controls multiple biological processes, and a specific class of small RNAs, called pi...
Fragile X syndrome (FraX), caused by the loss-of-function of one gene (FMR1), is the most common inh...
AbstractFragile X Syndrome (FraX) is the most common form of inherited mental retardation. The disea...
Fragile X syndrome (FXS) is the most common heritable form of intellectual disability and a known ge...
International audienceFMRP belongs to a family of widely expressed proteins that contain RNA-binding...
<div><p>Fragile X syndrome (FXS) is the most frequent inherited form of mental retardation. The caus...
Fragile X syndrome is the most common form of heritable mental retardation caused by the loss of fun...
AbstractFragile X mental retardation gene (FMR1) encodes an RNA binding protein that acts as a negat...
SUMMARY Fragile X syndrome (FXS), the most common inherited determinant of intellectual disability a...
AbstractBackground: Fragile X syndrome is caused by loss-of-function mutations in the fragile X ment...
The fragile X syndrome (FXS), the most common form of inherited intellectual disability, is due to t...
Fragile-X Syndrome represents the most common form of hereditary mental retardation. The disorder or...
International audienceABSTRACT RNA metabolism controls multiple biological processes, and a specific...
AbstractFragile X syndrome, the most common form of inherited mental retardation, is caused by loss ...
RNA metabolism controls multiple biological processes, and a specific class of small RNAs, called pi...
RNA metabolism controls multiple biological processes, and a specific class of small RNAs, called pi...
Fragile X syndrome (FraX), caused by the loss-of-function of one gene (FMR1), is the most common inh...
AbstractFragile X Syndrome (FraX) is the most common form of inherited mental retardation. The disea...
Fragile X syndrome (FXS) is the most common heritable form of intellectual disability and a known ge...
International audienceFMRP belongs to a family of widely expressed proteins that contain RNA-binding...
<div><p>Fragile X syndrome (FXS) is the most frequent inherited form of mental retardation. The caus...
Fragile X syndrome is the most common form of heritable mental retardation caused by the loss of fun...
AbstractFragile X mental retardation gene (FMR1) encodes an RNA binding protein that acts as a negat...
SUMMARY Fragile X syndrome (FXS), the most common inherited determinant of intellectual disability a...
AbstractBackground: Fragile X syndrome is caused by loss-of-function mutations in the fragile X ment...
The fragile X syndrome (FXS), the most common form of inherited intellectual disability, is due to t...
Fragile-X Syndrome represents the most common form of hereditary mental retardation. The disorder or...
International audienceABSTRACT RNA metabolism controls multiple biological processes, and a specific...
AbstractFragile X syndrome, the most common form of inherited mental retardation, is caused by loss ...
RNA metabolism controls multiple biological processes, and a specific class of small RNAs, called pi...
RNA metabolism controls multiple biological processes, and a specific class of small RNAs, called pi...
Fragile X syndrome (FraX), caused by the loss-of-function of one gene (FMR1), is the most common inh...
AbstractFragile X Syndrome (FraX) is the most common form of inherited mental retardation. The disea...