Communications

Aminophenyl-containing pyridines are of interest for their further functionalization leading to new heterocyclic systems.1 Moreover, they possess biological activity.2 On the other hand, 2-(het)arylpyridines are common ligands for various metal cations, some of them having found use as phos-phorescent labels for bioimaging.3 Aminoaryl-substituted deriva-tives of 2-(het)arylpyridines are good substrates for this purpose, as they can be readily converted into isothiocyanate ones by treat-ment with thiophosgene just before the bioconjugation.4 For the effective bioimaging these functional groups are usually separated from the metal chelating site, e.g., by aromatic sub stituent(s). A number of methods for the synthesis of aminophenyl-pyridines are described in literature.5,6 However, only one example based on 1,2,4-triazine methodology for the synthesis of amino-phenyl-containing pyridine7 is described, although this approac