Coregulation in human leukocytes of the long pentraxin PTX3 and TSG-6

The prototypic long PTX3 is a multifunctional protein in-volved in innate resistance to pathogens and in control-ling inflammation. TSG-6 is a hyaluronan-binding protein that is involved in ECM remodeling and has anti-inflam-matory and chondroprotective functions. PTX3 and TSG-6 are coregulated by growth differentiation fac-tor-9 in granulosa cells, where they are produced dur-ing the periovulatory period and play essential roles in the incorporation of hyaluronan into the ECM during cu-mulus expansion. The present study was designed to assess whether PTX3 and TSG-6 are coregulated in leukocytes, in particular, in phagocytes and DC. Mono-cytes, macrophages, and myeloid DC were found to produce high levels of TSG-6 and PTX3 in response t