Cyclic Nucleotide Concentrations in

ABSTRACT-Pancreas cancer was Induced In nonlnbred male Holtzman rats by the Implantation of beeswax containing 7,12-dlmethylbenz[a]anthracene (OMBA) Into the "head " of the pan-creas. The tumors that developed 4-6 months later were ex-amined for their cyclic AMP and cyclic GMP levels. The lesions could be considered In one of two categories according to their cyclic nucleotide contents: lesions with significantly smaller amounts and those with greater amounts, compared with levels measured In the pancreas tissues of the control rat.. The existence of two biochemically distinct groups may Indicate different growth patterns of the OMBA-Induced pancreatic neo-plasla.-J Natl Cancer Inst 61: 1281-1284, 1978. The pancreas is a highly specialized organ with two major biologic functions: exocrine secretion of various digestive enzymes by the acinar cells and endocrin