© 2010 Atlas of Genetics and Cytogenetics in Oncology and Haematology Identity

Note: MUC13 is a membrane bound mucin exhibiting abundant O- and N-glycosylation. The aberrant expression and localization of MUC13 may be involved in cancer pathobiology and could be a potential diagnostic/prognostic biomarker of cancer as well as a target for antibody guided therapy for cancer treatment. DNA/RNA Description Human MUC13 was originally identified as a ortholog of the previously identified murine MUC13 (Williams et al., 2001). Based on fluorescence in situ hybridization, MUC13 was originally identified at location 3q13.3 (Williams et al., 2001); however, MUC13 is now reported to be located on chromosome 3; location 3q21.2, MUC13 is flanked by ITGB5 (beta 5 integrin) and HEG-1 (Heart of Glass), each transcribed from the reverse strand. Schematic diagram of the genomic MUC13 DNA (including neighboring genes) and the transcript of MUC13. MUC13 is located on chromosome 3 between ITGB5 and HEG-1. These 3 genes are transcribed from the reverse strand. The MUC13 transcript contains 1