Journal of Feline Medicine and Surgery 0(0) 1 –7 © ISFM and AAFP 2012 Reprints and permission:

jfms.com A 6-month-old, 2.6 kg, neutered female domestic short-hair cat was presented for assessment of bilateral carpal swelling and hyperglobulinemia. Eighteen days previ-ously the cat had presented to the referring veterinarian for investigation of a non-weight-bearing left forelimb lameness. Left carpal swelling was identified and symp-tomatic treatment with 0.3 mg/kg parenteral meloxicam (Metacam; Boehringer Ingleheim) was provided. The cat subsequently developed a right forelimb lameness and examination 12 days after initial presentation revealed bilateral carpal swelling. Symptomatic treatment with oral meloxicam 0.1 mg/kg q24h; doxycycline (Vibravet; Pfizer) 5 mg/kg PO q24h and calcium carbonate (Calci-Tab 600; AFT Pharmaceuticals) 90 mg/kg PO q12h was administered, but there was no improvement. Forty-eight hours later the cat had deteriorated significantly. It was non-ambulatory but was able to stand with assistance; a mild mandibular lymphadenopathy was identified. Hematology and serum biochemistry panels were per-formed (Table 1). A differential white cell count was not provided; however, cytological examination of peripheral blood showed increased numbers of atypical, medium-sized lymphocytes. In-house tests were negative for feline immunodeficiency virus (FIV) antibodies and feline leukemia virus (FeLV) antigen (AGEN FeLV/FIV Simplify). Treatment with intravenous (IV) fluids (0.45 % sodium chloride and 2.5 % glucose), predniso-lone (Solone; Sigma Pharmaceuticals) 1.8 mg/kg PO q12h and a continuous rate infusion of butorphanol (Dolorex; Merck Animal Health) (0.04 mg/kg/h IV) were administered over 48 h and the cat’s demeanor improved; however, it remained non-ambulatory and was referred for assessment. Physical examination revealed a small stature and pallor. The cat was unable to stand without assistance. Swelling and malalignment of both carpi, pain on Polyostotic lymphoma with multiple pathological fractures in a six-month-old ca