1 Systematic Determination of Human Cyclin Dependent Kinase (CDK)-9 Interactome Identifies Novel Functions in RNA Splicing Mediated by the

The abbreviations used are: BRD4, bromodomain containing 4; CAN508, 4-(3,5-Diamino-1H-pyrazol-4-ylazo)-phenol; CDK9, cyclin dependent kinase 9; DDX5/17, DEAD-box RNA helicase 5/17; FDR, false discovery rate; GO, gene ontology; HEXIM, hexamethylene bis-acetamide inducible; HOA1, hydroxyacid oxidase 1; IP, immunoprecipitation;LC-MS/MS, Liquid chromatography- tandem mass spectrometry; NF-B, nuclear factor kappa-light-chain-enhancer of activated B cells; Poly (I:C), polyinosinic:polycytidylic acid; P-TEFb, the positive transcription elongation factor complex; PPI, protein-protein interactions; Q-gPCR, quantitative genomic real time PCR; Q-RT-PCR, quantitative reverse transcription real time PCR; RFESD, Rieske (Fe-S) domain containing; ROS, reactive oxygen species; RP, ribosomal protein; SAEC, small airway epithelial cells; shRNA, small or short hairpin RNA; SOD3, extracellular superoxide dismutase 3; SRM, selected reaction monitoring; STAT1, signal transducer and activator of transcription 1; XChIP, two-step cross-linking chromatin immunoprecipitation.