OPEN ACCESS OJVM Electroencephalographic Recordings in the Canine: Effects of Low Dose Medetomidine or Dexmedetomidine Followed by Atipamezole*

Copyright © 2014 Laura C. Tepper, Andy Shores. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. In accordance of the Creative Commons Attribution License all Copyrights © 2014 are reserved for SCIRP and the owner of the intellectual property Laura C. Tepper, Andy Shores. All Copyright © 2014 are guarded by law and by SCIRP as a guardian. Objectives: 1) To describe electroencephalogram (EEG) appearance in the awake dog and compare these results with EEG recordings after low dose medetomidine (2 µg/kg IV) followed by atipamezole (10 µg/kg, IM); 2) To institute EEG recordings after low dose medetomidine or dexmedetomidine as a standard of practice if focal ab-normalities and amplitudes were not significantly altered by pharmaceuticals in Phase 1 of this study. Methods: Electroencephalograms were performed on eight clinical canine patients with suspected intracranial disease in-volving the prosencephalon. A five lead montage was used to record the EEGs. Each dog had an awake, baseline recording followed by an EEG performed after administration of low dose medetomidine (2 µg/kg IV) then ati-pamezole (10 µg/kg, IM). In the second phase of this study, the same dose of medetomidine or dexmedetomidine at 1 µg/kg IV and atipamezole (10 µg/kg, IM) were used in the evaluation of 20 clinical patients with suspected neurologic disease. Results: In Phase 1, awake recordings were laced with movement artifacts. After medetomi