Binding Study of Naringenin Derivatives and Cyclin Dependent Kinase 2

It has been reported that antioxidant activities of herbs are caused by phenolic compounds, which can be classified based on their carbon skeletons.1 Among several classes of phenolic compounds, a group with the core structure of C6-C3-C6 is named flavonoids (benzo-γ-pyran derivatives), consisting of phenolic and pyran rings. According to the oxidation state of pyran ring, flavonoids can be further subdivided into five major subclasses as follows: flavonols, flavanols, flavones, isoflavones, and anthocyanidins.2 These structures can be varied by methylation, hydrogenation, hydroxylation, glycosylation, and so on. Flavonoids show many biological activities including apoptotic effects. Since apoptosis is one of the methods to control tumor formation, compounds inducing apoptosis can be considered as anti-tumor agents. On the other hand, cyclin dependent kinases