Hepatocarcinogenesis in hepatitis B virus trans-genic mice was studied by means of a correlative cyto-morphological and cytochemical approach at different time points in animals from 1 to 34 mo old. HBsAg-positive ground-glass hepatocytes emerged throughout the liver parenchyma in nearly all transgenic mice during the first 4 mo after birth. The panlobular ex-pression of HBsAg persisted until foci of altered hepa-tocytes appeared (6 to 9 mo of age). Three different types of foci of altered hepatocytes- namely, glycogen-storage foci, mixed cell foci and glycogen-poor foci-developed. Hepatocellular adenomas and carcinomas appeared after 11 mo. Orcein staining revealed fre-quent transitions between ground-glass hepatocytes extensively expressi...
BACKGROUND AND AIMS: A histopathological hallmark of chronic hepatitis B virus (HBV) infection is th...
<div><p>Background</p><p>Hepatocellular carcinoma (HCC) is a common complication of chronic viral he...
Hepatocellular carcinoma (HCC) is a deadly disease, often unnoticed until the late stages, when trea...
Background: The introduction of transgenic technology has made it possible to study the steps of car...
OBJECTIVES: Large liver cell dysplasia (LCD) is frequently associated with hepatitis B virus (HBV), ...
Hepatocellular carcinoma (HCC), the third leading cause of cancer deaths worldwide, is most commonly...
[[abstract]]The Hepatitis B Virus X (HBx) protein has been strongly implicated in the carcinogenesis...
Background/Aims: Chronic infection with hepatitis B virus is a high- risk factor for hepatocellular ...
Hepatocellular carcinoma (HCC) is a common complication of chronic viral hepatitis. In support of th...
The cell of origin of hepatoblastoma (HB) in humans and mice is unknown; it is hypothesized to be a ...
Background: While the immune pathogenesis caused by hepatitis B virus (HBV) infection has been studi...
BACKGROUND AND AIMS: Understanding the molecular pathogenesis of hepatocellular carcinoma (HCC) is e...
[[abstract]]The discovery of "ground glass" hepatocytes (GGH) that contain hepatitis B virus (HBV) s...
Hepatitis B virus (HBV) is one of the major etiological factors responsible for the development of h...
[[abstract]]Hepatocellular carcinoma (HCC) is among the ten most commonly diagnosed cancers and the ...
BACKGROUND AND AIMS: A histopathological hallmark of chronic hepatitis B virus (HBV) infection is th...
<div><p>Background</p><p>Hepatocellular carcinoma (HCC) is a common complication of chronic viral he...
Hepatocellular carcinoma (HCC) is a deadly disease, often unnoticed until the late stages, when trea...
Background: The introduction of transgenic technology has made it possible to study the steps of car...
OBJECTIVES: Large liver cell dysplasia (LCD) is frequently associated with hepatitis B virus (HBV), ...
Hepatocellular carcinoma (HCC), the third leading cause of cancer deaths worldwide, is most commonly...
[[abstract]]The Hepatitis B Virus X (HBx) protein has been strongly implicated in the carcinogenesis...
Background/Aims: Chronic infection with hepatitis B virus is a high- risk factor for hepatocellular ...
Hepatocellular carcinoma (HCC) is a common complication of chronic viral hepatitis. In support of th...
The cell of origin of hepatoblastoma (HB) in humans and mice is unknown; it is hypothesized to be a ...
Background: While the immune pathogenesis caused by hepatitis B virus (HBV) infection has been studi...
BACKGROUND AND AIMS: Understanding the molecular pathogenesis of hepatocellular carcinoma (HCC) is e...
[[abstract]]The discovery of "ground glass" hepatocytes (GGH) that contain hepatitis B virus (HBV) s...
Hepatitis B virus (HBV) is one of the major etiological factors responsible for the development of h...
[[abstract]]Hepatocellular carcinoma (HCC) is among the ten most commonly diagnosed cancers and the ...
BACKGROUND AND AIMS: A histopathological hallmark of chronic hepatitis B virus (HBV) infection is th...
<div><p>Background</p><p>Hepatocellular carcinoma (HCC) is a common complication of chronic viral he...
Hepatocellular carcinoma (HCC) is a deadly disease, often unnoticed until the late stages, when trea...