Low Plasma Adiponectin Concentrations Do Not Predict Weight Gain in Humans

abundant adipose-specific protein, are observed in obese individuals and predict the development of type 2 diabetes. Administration of adiponectin to rodents pre-vented diet-induced weight gain, suggesting a potential etiologic role of hypoadiponectinemia in the develop-ment of obesity. Our aim was to prospectively examine whether low plasma adiponectin concentrations predict future weight gain in Pima Indians, explaining the pre-dictive effect of adiponectin on the development of type 2 diabetes. We measured plasma adiponectin concentra-tions in 219 nondiabetic Pima Indians (112 M/107 F, age 31 9 years, body weight 96 20 kg [mean SD]) in whom body weight and height were measured and BMI calculated at baseline and follow-up. Cross-sectionally, plasma adiponectin concentrations were negatively as