(“synthetic lethality”) can arise as a consequence of the genetic abnormalities in cancer cells, as illustrated by the sensitivity of BRCA1/2-mutant breast cancer cells to PARP inhibitors (7, 8). The systematic identification of such synthetic lethal relationships might suggest new drug targets (9). Comparison of the genetic abnormalities and functional vulnerabilities of cancer cells should help researchers identify new drivers and provide insight into the complex systems biology of cancer. RNA interference technology has enabled genome-wide loss-of-function screens in mammalian cells. Most screens have used siRNAs, usually arrayed in multiwell plates. Arrayed screens have focused mainly on specific gene fami-lies...
To access publisher full text version of this article. Please click on the hyperlink in Additional L...
The following document contains a manuscript-based Masters of Science (MSc.) thesis submission for N...
PURPOSE: Cis-acting regulatory SNPs resulting in differential allelic expression (DAE) may, in part...
(“synthetic lethality”) can arise as a consequence of the genetic abnormalities in cancer cells, a...
In order to foster the systematic identification of novel genes with important functional roles in p...
To access publisher full text version of this article. Please click on the hyperlink in Additional L...
Germline mutations in the tumour suppressor genes breast cancer antigen gene (BRCA)1 and BRCA2 have ...
Genetic linkage studies have led to the identification of highly penetrant genes as the possible cau...
ABSTRACT Here, we use a large-scale cell line–based approach to identify cancer cell–specifi c mutat...
Background: Genomic aberration is a common feature of human cancers and also is one of the basic mec...
Background: CHEK2*1100delC is a moderate-risk breast cancer susceptibility allele with a high preval...
Familial Pancreatic Cancer (FPC) is a cancer syndrome characterized by clustering of pancreatic canc...
polymorphisms in sporadic and hereditary breast cancer José da Silva Nogueira Junior1†, Fernando Aug...
Basal-like breast cancer is an aggressive subtype generally characterized as poor progno-sis and lac...
Breast cancer is considered to display a high degree of intratumor heterogeneity, without any obviou...
To access publisher full text version of this article. Please click on the hyperlink in Additional L...
The following document contains a manuscript-based Masters of Science (MSc.) thesis submission for N...
PURPOSE: Cis-acting regulatory SNPs resulting in differential allelic expression (DAE) may, in part...
(“synthetic lethality”) can arise as a consequence of the genetic abnormalities in cancer cells, a...
In order to foster the systematic identification of novel genes with important functional roles in p...
To access publisher full text version of this article. Please click on the hyperlink in Additional L...
Germline mutations in the tumour suppressor genes breast cancer antigen gene (BRCA)1 and BRCA2 have ...
Genetic linkage studies have led to the identification of highly penetrant genes as the possible cau...
ABSTRACT Here, we use a large-scale cell line–based approach to identify cancer cell–specifi c mutat...
Background: Genomic aberration is a common feature of human cancers and also is one of the basic mec...
Background: CHEK2*1100delC is a moderate-risk breast cancer susceptibility allele with a high preval...
Familial Pancreatic Cancer (FPC) is a cancer syndrome characterized by clustering of pancreatic canc...
polymorphisms in sporadic and hereditary breast cancer José da Silva Nogueira Junior1†, Fernando Aug...
Basal-like breast cancer is an aggressive subtype generally characterized as poor progno-sis and lac...
Breast cancer is considered to display a high degree of intratumor heterogeneity, without any obviou...
To access publisher full text version of this article. Please click on the hyperlink in Additional L...
The following document contains a manuscript-based Masters of Science (MSc.) thesis submission for N...
PURPOSE: Cis-acting regulatory SNPs resulting in differential allelic expression (DAE) may, in part...