In vitro and in vivo antioxidant activity of Ixora coccinea

of root of I. coccinea extract was evaluated in a series of in vitro assay involving free radicals. IC50 values were determined. Extracts of I. coccinea exhibited scavenging effect in concentration dependent manner in all in vitro method. IC50 of ethyl acetate extract was 48.43, 75.811 and 60.60 µg/ml for 2,2-diphenylpicrylhydrazyl (DPPH) radical scavenging, hydrogen peroxide scavenging, nitric oxide scavenging, respectively. Ethyl acetate extract shows good in vitro antioxidant activity compared to other extract. The extract was also studied for in vivo antioxidant activity by prolongation of haloperidol induced catalepsy. Methanolic extract shows good in vivo antioxidant activity compared to other extract. Key words: Ixora coccinea, DPPH free radical, nitric oxide radical, hydrogen peroxide scavenging, haloperido