The sensitivity of Pseudomonas pseudomallei to trimethoprim and sulphamethoxazole

SYNOPSIS Twelve out of 14 strains of Pseudomonas pseudomallei were inhibited in vitro by a combi-nation of trimethoprim 1,ug per ml and sulphamethoxazole 20,ug per ml or by lower concentrations. Of the remaining strains, one was marginally more resistant and one was distinctly so. In tests utilizing two of the sensitive strains, inhibitory concentrations of the individual drugs exerted a bactericidal effect when combined. Recent American experience of cases of melioidosis from Vietnam has led to renewed interest in the problems of antibiotic treatment and chemotherapy in this disease. Most commonly, high dosages of combinations of antibiotics have been used, and a minimum of four weeks ' treatment has been accepted as necessary because of the danger of relaps