Add to ORKGAim: To investigate the patterns of inheritance and gene mutation status in early-onset dementia (EOD). Methods: Data were collected on 202 consecutive patients presenting to an EOD clinic. Early-onset Alzheimer’s disease (EOAD, n 120) and early-onset frontotemporal dementia (EOFTD, n 82) were studied. Results: The majority of participants, 72.5 % with EOAD and 74.4 % with EOFTD, did not have a positive family history of dementia. An autosomal dominant pattern of inheritance was observed in 14.2 % of patients with EOAD and 13.4 % of patients with FTD. Of those with an autosomal dominant pattern of inheri-tance, 11.8 % of EOAD and 45.5 % of FTD probands had known pathogenic mutations. Only 1.6 % of the total population of EOAD and 7.3 % of...
International audienceBackground:Pathogenic variants in the autosomal dominant genes PSEN1, PSEN2, o...
) mutations cause autosomal dominant forms of early-onset Alzheimer disease (AD-EOAD). Although thes...
Heterozygous mutations in the genes for amyloid precursor protein (APP), the presenilins (PS1, PS2),...
Aim: To investigate the patterns of inheritance and gene mutation status in early-onset dementia (EO...
Background: Major breakthroughs in dementia research were realized in studying large families with a...
Background: Major breakthroughs in dementia research were realized in studying large families with a...
Alzheimer’s disease (AD) is the most common progressive neurodegenerative disease and the most commo...
SummaryTo determine the prevalence of early-onset Alzheimer disease (EOAD) and of autosomal dominant...
Background: Early onset dementias (EOD) are rare neurodegenerative dementias that present before 65 ...
Alzheimer’s disease (AD), Parkinson’s disease (PD), frontotemporal dementia (FTD), amyot...
Alzheimer’s disease (AD) is the most common type of dementia. It is estimated that more than 35 mill...
BackgroundEarly onset dementias (EOD) are rare neurodegenerative dementias that present before 65 ye...
International audienceBackground:Pathogenic variants in the autosomal dominant genes PSEN1, PSEN2, o...
) mutations cause autosomal dominant forms of early-onset Alzheimer disease (AD-EOAD). Although thes...
Heterozygous mutations in the genes for amyloid precursor protein (APP), the presenilins (PS1, PS2),...
Aim: To investigate the patterns of inheritance and gene mutation status in early-onset dementia (EO...
Background: Major breakthroughs in dementia research were realized in studying large families with a...
Background: Major breakthroughs in dementia research were realized in studying large families with a...
Alzheimer’s disease (AD) is the most common progressive neurodegenerative disease and the most commo...
SummaryTo determine the prevalence of early-onset Alzheimer disease (EOAD) and of autosomal dominant...
Background: Early onset dementias (EOD) are rare neurodegenerative dementias that present before 65 ...
Alzheimer’s disease (AD), Parkinson’s disease (PD), frontotemporal dementia (FTD), amyot...
Alzheimer’s disease (AD) is the most common type of dementia. It is estimated that more than 35 mill...
BackgroundEarly onset dementias (EOD) are rare neurodegenerative dementias that present before 65 ye...
International audienceBackground:Pathogenic variants in the autosomal dominant genes PSEN1, PSEN2, o...
) mutations cause autosomal dominant forms of early-onset Alzheimer disease (AD-EOAD). Although thes...
Heterozygous mutations in the genes for amyloid precursor protein (APP), the presenilins (PS1, PS2),...