Original Communication Clinical Relevancy Statement

Nonalcoholic fatty liver disease (NAFLD) is a common liver disease in obese children and can range in severity from a simple fatty liver to more serious liver disease that includes both inflammation and fibrosis (nonalcoholic steatohepatitis or NASH) to cirrhosis. Although optimizing dietary intake and physical activity may mediate metabolic dysregulation in NAFLD, very little is known regarding the extent to which acute intakes of high saturated fat/low long-chain polyunsatu-rated fatty acids (particularly n-3 and n-6) influence disease onset and postprandial metabolism in obese children. Implications for treatment are discussed