COMPOUND PER CENT OP

There has recently been introduced a series of sympathomimetic compounds related to the /3-phenylethylamines, but with a cyclohexyl ring replacing the phenyl group (1-4). The relationship between structure and oxidation by amine oxidase has been extensively studied for the 3-phenylethylamines by Beyer (5), and the excretion of a number of these compounds by the rat has been the subject of a recent communication from this laboratory (6). Con-sequently it appeared worth while to investigate the influence of methyl sub-stitution on the metabolism of the fl-cyclohexylethylamines. METHODS. The procedures used were the same as those previously employed in a study of substituted fl-phenylethylamines (6). The influence of amine oxidase was studied in the conventional Warburg apparatus. The flasks contained 0.0025 mmol. of the amine hydrochloride and 1 cc. of rabbit or guinea pig liver homogenate buffered at pH 7.2. The enzyme preparations were used either at A SPET Journals on