Synthesis of TAAR Regulators Utilizing a Novel Urea Linkage

Unfortunately, there is still a worldwide problem dealing with poor thyroid conditions that limit the effectiveness of the organ\u27s ability to maintain homeostasis. The trace amine associated receptors, also referred to as TAAR, are G-protein coupled receptors that bind with a thyroid hormone metabolite in the body producing immediate physiological effects such as decreased heart rate, body temperature, and metabolism. Our lab has been synthesizing novel ligands for TAAR that regulate its activity. Specifically, this presentation covers the creation of urea derivatives based on a potent activator for TAAR. Small molecule regulators could potentially balance the thyroid hormones effect on homeostasis in the body. These compounds will be evaluated in bio-assays to give us more clues about the molecular basis of TAAR activation and may lead to a greater understanding of its role in biology