This paper rigorously derives a general probabilistic model for the PCR process; this model includes as a special case the Velikanov-Kapral model where all nucleotide reaction rates are the same. In this model the probability of binding of deoxy-nucleoside triphosphate (dNTP) molecules with template strands is derived from the microscopic chemical kinetics. A recursive solution for the probability distribution of binding of dNTPs is developed for a single cycle and is used to calculate expected yield for a multicycle PCR. The model is able to reproduce important features of the PCR amplification process quantitatively. With a set of favorable reaction conditions, the amplification of the target sequence is fast enough to rapidly outnumber a...
We propose a stochastic modelling of the PCR amplification process by a size-dependent branching pro...
Polymerase chain reaction (PCR) is a major DNA amplification technology from molecular biology. The ...
In this paper, we generalise a previously-described model of the error-prone polymerase chain reacti...
Earlier work by Saha et al. rigorously derived a general probabilistic model for the PCR process tha...
A probabilistic approach to the kinetics of the polymerase chain reaction (PCR) is developed. The ap...
A new stochastic approach to model Polymerase Chain Reaction (PCR) kinetic is presented, in which pr...
Despite the fact that PCR is a powerful tool in modern biology and medicine, its quantitative model ...
Introduction The polymerase chain reaction (PCR) is a method that uses test tubes in biological lab...
We propose a stochastic modelling of the PCR amplification process by a size-dependent branching pro...
We propose a stochastic modelling of the PCR amplification process by a size-dependent branching pro...
We propose a stochastic modelling of the PCR amplification process by a size-dependent branching pro...
We propose a stochastic modelling of the PCR amplification process by a size-dependent branching pro...
We propose a stochastic modelling of the PCR amplification process by a size-dependent branching pro...
A stochastic model for the efficiency of polymerase chain reaction (PCR) processes is presented. The...
Polymerase chain reaction (PCR) is a major DNA amplification technology from molecular biology. The ...
We propose a stochastic modelling of the PCR amplification process by a size-dependent branching pro...
Polymerase chain reaction (PCR) is a major DNA amplification technology from molecular biology. The ...
In this paper, we generalise a previously-described model of the error-prone polymerase chain reacti...
Earlier work by Saha et al. rigorously derived a general probabilistic model for the PCR process tha...
A probabilistic approach to the kinetics of the polymerase chain reaction (PCR) is developed. The ap...
A new stochastic approach to model Polymerase Chain Reaction (PCR) kinetic is presented, in which pr...
Despite the fact that PCR is a powerful tool in modern biology and medicine, its quantitative model ...
Introduction The polymerase chain reaction (PCR) is a method that uses test tubes in biological lab...
We propose a stochastic modelling of the PCR amplification process by a size-dependent branching pro...
We propose a stochastic modelling of the PCR amplification process by a size-dependent branching pro...
We propose a stochastic modelling of the PCR amplification process by a size-dependent branching pro...
We propose a stochastic modelling of the PCR amplification process by a size-dependent branching pro...
We propose a stochastic modelling of the PCR amplification process by a size-dependent branching pro...
A stochastic model for the efficiency of polymerase chain reaction (PCR) processes is presented. The...
Polymerase chain reaction (PCR) is a major DNA amplification technology from molecular biology. The ...
We propose a stochastic modelling of the PCR amplification process by a size-dependent branching pro...
Polymerase chain reaction (PCR) is a major DNA amplification technology from molecular biology. The ...
In this paper, we generalise a previously-described model of the error-prone polymerase chain reacti...