Reproductive and Developmental Toxicity Studies of a Linear Alkylbenzene Mixture in Rats. ROBINSON, E. C. AND

Alkylate 215, a mixture of linear decyl- to tridecylbenzenes, is an intermediate in the manufacture of detergent sulfonates. A two-generation reproduction study and a developmental toxicity study were conducted using single daily doses given by gastric intubation in a corn oil vehicle. In the reproduction study, groups of 30 rats/sex/group were given doses of 0, 5, 50, or 500 mg/kg/day. Fo animals received a 10-week pre-niating treatment period and were then mated to produce a single litter; F, adults were selected from the F, litters. F, animals were dosed for 11 weeks before mating to produce a single litter. Adults and weaned pups received a gross post-mortem examination. Histopathology studies were conducted on reproductive tissues, tissues with gross lesions, and the pituitary gland taken from each adult in the control and high dose groups. In the developmental toxicity study, groups o