Manuscript published in the journal Medical Science Monitor

In this paper, we present a Millimeter-wave BioMEMS (Biological MicroElectro-Mechanical System) dedicated to the ex vivo detection of nitric oxide synthase (NOS) activity. The latter is involved in neurodegenerative phenomena. The BioMEMS is fabricated by using polydimethylsiloxane (PDMS) sealed on a glass substrate supporting gold coplanar waveguides (CPWs). The NOS activity detection is performed by Millimeter-wave (MMW) transmission signals through CPWs placed under the lesion site of an immobilised leech nerve cord. Tests are carried out in the frequency range 140-220 GHz, and the results obtained show that MMW transmission spectroscopy combined with microfluidic technology can be used for monitoring biochemical events in aqueous environment and consequently in biological models. PACS. 87.85.Ox Biomedical instrumentation and transducers, including micro-electro-mechanical systems (MEMS) – 41.20.-q Applied classical electromagnetism (for submillimeter wave, microwave, and radiowave instruments and equipment