Human embryonic germ cells (EGCs) provide a powerful model for identifying molecules involved in the pluripotent state when compared to their progenitors, primordial germ cells (PGCs), and other pluripotent stem cells. Microarray and Principal Component Analysis (PCA) reveals for the first time that human EGCs possess a transcription profile distinct from PGCs and other pluripotent stem cells. Validation with qRT-PCR confirms that human EGCs and PGCs express many pluripotency-associated genes but with quantifiable differences compared to pluripotent embryonic stem cells (ESCs), induced pluripotent stem cells (IPSCs), and embryonal carcinoma cells (ECCs). Analyses also identified a number of targe
Human primordial germ cells (hPGCs) are the first embryonic progenitors in the germ cell lineage, ye...
Embryonic stem (ES) cells are derived from blastocysts. They can differentiate into the three embryo...
The study of primordial germ cell development in vivo is hampered by their low numbers and inaccessi...
<div><p>Human embryonic germ cells (<b>EGCs</b>) provide a powerful model for identifying molecules ...
In humans, germline competency and the specification of primordial germ cells (PGCs) are thought to ...
The molecular mechanism underlying pluripotency is largely unknown. Here, we provide the first globa...
The derivation of human embryonic cells (hESCs) from human blastocysts represents one of the milesto...
Primordial germ cells (PGCs), the precursors of gametes, are specified in early post-implantation hu...
Researchers have cultured cells that look and act like human primordial germ cells (PGCs)—and they h...
Primordial germ cells (PGCs) have long been considered the link between one generation and the next....
SummaryPluripotent stem cells derived from both embryonic and reprogrammed somatic cells have signif...
AbstractThe molecular mechanism underlying pluripotency is largely unknown. Here, we provide the fir...
Historically, our understanding of molecular genetic aspects of human germ cell development has been...
© 2016 Japan Society for Ova Research.Mammalian primordial germ cells (PGCs) are specified in the ea...
Pluripotent embryonic germ cells (EGCs) can be derived from the culture of primordial germ cells (PG...
Human primordial germ cells (hPGCs) are the first embryonic progenitors in the germ cell lineage, ye...
Embryonic stem (ES) cells are derived from blastocysts. They can differentiate into the three embryo...
The study of primordial germ cell development in vivo is hampered by their low numbers and inaccessi...
<div><p>Human embryonic germ cells (<b>EGCs</b>) provide a powerful model for identifying molecules ...
In humans, germline competency and the specification of primordial germ cells (PGCs) are thought to ...
The molecular mechanism underlying pluripotency is largely unknown. Here, we provide the first globa...
The derivation of human embryonic cells (hESCs) from human blastocysts represents one of the milesto...
Primordial germ cells (PGCs), the precursors of gametes, are specified in early post-implantation hu...
Researchers have cultured cells that look and act like human primordial germ cells (PGCs)—and they h...
Primordial germ cells (PGCs) have long been considered the link between one generation and the next....
SummaryPluripotent stem cells derived from both embryonic and reprogrammed somatic cells have signif...
AbstractThe molecular mechanism underlying pluripotency is largely unknown. Here, we provide the fir...
Historically, our understanding of molecular genetic aspects of human germ cell development has been...
© 2016 Japan Society for Ova Research.Mammalian primordial germ cells (PGCs) are specified in the ea...
Pluripotent embryonic germ cells (EGCs) can be derived from the culture of primordial germ cells (PG...
Human primordial germ cells (hPGCs) are the first embryonic progenitors in the germ cell lineage, ye...
Embryonic stem (ES) cells are derived from blastocysts. They can differentiate into the three embryo...
The study of primordial germ cell development in vivo is hampered by their low numbers and inaccessi...