J Vet Diagn Invest 3:137-143 (1991) Experimental equine herpesvirus-l infection in llamas (Lama glama)

Abstract. Three llamas (Lama glama) were experimentally infected intranasally with an isolate of equine herpesvirus-1 (EHV-1) from the brain of an alpaca that had experienced severe neurologic signs. Two of the 3 llamas developed severe neurologic disorders following inoculation; 1 died, and 1 was euthanized in a moribund state. The third llama showed only mild neurologic signs. The euthanized llama had preexisting antibodies to-EHV-1, and the remaining 2 llamas were seronegative (virus neutralization titer < 6) at the time of inoculation. One of the seronegative llamas died acutely without production of detectable antibodies, and the other developed antibodies typical of a primary immune response. The EHV-1 virus was recovered only from a sample of the thalamus of the llama that died acutely. Histopathologic lesions were observed in the brain and retina of the dead and euthanized animals. This study verifies the pathogenic potential of EHV-1 for llamas. Equine herpesvirus-1 (EHV-1) infection causes a re-spiratory disease (rhinopneumonitis) that is most fre-quently seen in foals and yearlings.3,15,22 In pregnant mares, EHV-1 is a major cause of abortion storms in late gestation. In addition, neurologic disturbances as-sociated with an encephalomyelitis may occur in ma