Clinical research Arrhythmia/electrophysiology Familial aggregation of atrial fibrillation in Iceland

Aims To examine the heritability of atrial fibrillation (AF) in Icelanders, utilizing a nationwide genealogy database and population-based data on AF. AF is a disorder with a high prevalence, which has been known to cluster in families, but the heritability of the common form has not been well defined. Methods and results The study population included 5269 patients diagnosed since 1987 and age-sex-matched controls randomly selected from the genealogy database. Kinship coefficients (KC), expressed as genealogical index of familiality (GIF average KC 100 000), were calculated before and after exclusion of relatives separated by one to five meiotic events. Risk ratios (RR) were calculated for first- to fifth-degree relatives. The average pairwise GIF among patients with AF was 15.9 (mean GIF for controls 13.9, 95%CI 13.3, 14.4); this declined to 15.4 (mean GIF for controls 13.6, 95%CI 13.1, 14.2) after exclusion of relatives separated by one meiosis and to 13.7 (mean GIF for con-trols 12.6, 95%CI 12.1, 13.2), 12.7 (mean GIF for controls 11.9, 95%CI 11.4, 12.4), and 11.3 (mean GIF for controls 10.6, 95%CI 10.1, 11.1) after exclusion of relatives within two, three, and four meioses, respectively (all P, 0.00001). RRs among relative pairs also declined incrementally, from 1.77 in first-degree relatives to 1.36, 1.18, 1.10, and 1.05 in second- through fifth-degree relatives (all P, 0.001), consistent with the declining proportion of alleles shared identically by descent