468 Vet Pathol 40:4, 2003Brief Communications and Case Reports Vet Pathol 40:468–473 (2003) Cardiomyopathy Associated with Angiomatous Pheochromocytoma in a Rhesus

Abstract. A 24-year-old female rhesus macaque (Macaca mulatta) presented with a clinical history of chronic heart disease and prolonged recovery from sedation and anesthesia. At necropsy, the heart was markedly enlarged, with thinned ventricular walls, dilated chambers, and severe left atrioventricular valvular insufficiency. The ventricular walls contained numerous narrow, pale, often coalescing streaks that often extended along vessels into the deeper myocardium. Histologically, bands of interstitial fibrosis in the heart were associated with areas of myofiber atrophy, myofibril degeneration and loss, and inflammation. The left adrenal gland contained a 2 1 0.5 cm tumor with an unusual angiomatous pattern consisting largely of blood-filled sinusoids lined by one to four layers of low cuboidal to polyhedral tumor cells. In most sinusoids, the tumor cells appeared to be in direct contact with blood, although endothelial cells lined some sinusoids. Ultrastruc-turally, the tumor cells contained abundant electron-dense cytoplasmic granules. These granules were argyro-philic by Sevier-Munger staining and intensely immunoreactive for synaptophysin, chromogranin A, neuron-specific enolase, and S-100. These findings helped confirm the diagnosis of angiomatous pheochromocytoma. The heart lesions match those reported for catecholamine cardiomyopathy in other species. Key words: Adrenal gland; cardiomyopathy; immunohistochemistry; pheochromocytoma; rhesus monkeys. Pheochromocytomas are neuroendocrine tumors arisin