Efficacy and Toxicity of Sodium Stibogluconate for

Objective: To determine the efficacy and toxicity of the World Health Organization's (WHO) recommended treatment for mucosal leishmaniasis: antimony, 20 mg/kg body weight per day for 28 days. Design: Open trial with 12-month follow-up. Setting: Inpatient unit of a regional referral hospital in a developing country. Patients: Twenty-nine consecutive eligible patients with culture-confirmed infection of the mucosa with Leishmania species who were otherwise healthy. Eight patients (28%) had mild to moderate disease (confined to the nasal mucosa). Twenty-one patients (72%) had severe disease (including the oropharynx as well as the nasal mucosa). Intervention: Antimony, 20 mg/kg body weight intravenously every day for 28 days. Patients received antimony in the form o