ON BEHALF OF THE NATIONAL DIABETES

OBJECTIVE—We assessed the association between different blood lipid measures and risk of fatal/nonfatal coronary heart disease (CHD). RESEARCH DESIGN AND METHODS—We conducted an observational study of patients with type 2 diabetes from the Swedish National Diabetes Register. Baseline LDL cho-lesterol, non-HDL cholesterol, ratio of non-HDL to HDL cholesterol (non-HDL:HDL), and ratio of triacylglycerol to HDL cholesterol (TG:HDL) was measured in 18,673 patients aged 30–70 years, followed for a mean of 4.8 years from 2003 to 2007. RESULTS—Hazard ratios (HRs) for CHD per 1-SD increment in lipidmeasures were 1.23 with the non-HDL:HDL, 1.20 with non-HDL cholesterol, 1.17 with LDL cholesterol, and 1.15 with TG:HDL (all P, 0.001 when adjusted for clinical characteristics and nonlipid risk factors). The best global model fit was found with non-HDL:HDL. When patients within the lowest tertile of a lipid measure were compared with those with all lipid measures within the highest tertile, the adjusted HR for CHD was 0.62 with non-HDL:HDL,3.5 mmol/L, 0.65 with non-HDL choles-terol,3.3 mmol/L, and 0.70 with LDL cholesterol,2.5 mmol/L (all P, 0.001). The lowest tertile of LDL and non-HDL cholesterol corresponded with treatment targets according to U.S