Add to ORKGInterneuron dysfunction in humans is often associated with neuro-logical and psychiatric disorders, such as epilepsy, schizophrenia, and autism. Some of these disorders are believed to emerge during brain formation, at the time of interneuron specification, migration, and synapse formation. Here, using a mouse model and a host of his-tological and molecular biological techniques, we report that the sig-naling molecule cyclin-dependent kinase 5 (Cdk5), and its activator p35, control the tangential migration of interneurons toward and within the cerebral cortex by modulating the critical neurodevelop-mental signaling pathway, ErbB4/phosphatidylinositol 3-kinase, that has been repeatedly linked to schizophrenia. This finding identifies Cdk5 as...
A set of different protein kinases have been involved in tau phosphorylations, including glycogen sy...
<div><p>Protein phosphorylation is the most common post-translational modification that regulates se...
Cyclin-dependent kinase 5 is activated by small subunits, of which p35 is the most abundant. The fun...
Interneuron dysfunction in humans is often associated with neuro-logical and psychiatric disorders, ...
Interneuron dysfunction is often associated with neurological and psychiatric disorders, such as epi...
This thesis has focussed on the role of cyclin-dependent kinase 5 (Cdk5) and its activator, p35, in ...
Perturbations in fast-spiking parvalbumin (PV) interneurons are hypothesized to be a major component...
Cyclin-dependent kinase 5 (Cdk5) activity is dependent on its associationwith 1 of 2 neuron-specific...
AbstractCyclin-dependent kinase 5 (Cdk5) is much more than its name implies; it plays a role in neur...
DoctorIdentifying novel regulatory mechanisms of neurotransmitter receptor-mediated signaling has gr...
AbstractCyclin-dependent kinase 5 (Cdk5) is much more than its name implies; it plays a role in neur...
Cyclin-dependent kinase 5 (Cdk5), a member of the Cdks family, is identified to play a critical role...
Cyclin-Dependent Kinase-Like 5 (CDKL5) is a serine/threonine protein kinase important for neuronal d...
AbstractThe adult mammalian cortex is characterized by a distinct laminar structure generated throug...
Migration of neurons to their proper position underlies mammalian brain development. To remain on th...
A set of different protein kinases have been involved in tau phosphorylations, including glycogen sy...
<div><p>Protein phosphorylation is the most common post-translational modification that regulates se...
Cyclin-dependent kinase 5 is activated by small subunits, of which p35 is the most abundant. The fun...
Interneuron dysfunction in humans is often associated with neuro-logical and psychiatric disorders, ...
Interneuron dysfunction is often associated with neurological and psychiatric disorders, such as epi...
This thesis has focussed on the role of cyclin-dependent kinase 5 (Cdk5) and its activator, p35, in ...
Perturbations in fast-spiking parvalbumin (PV) interneurons are hypothesized to be a major component...
Cyclin-dependent kinase 5 (Cdk5) activity is dependent on its associationwith 1 of 2 neuron-specific...
AbstractCyclin-dependent kinase 5 (Cdk5) is much more than its name implies; it plays a role in neur...
DoctorIdentifying novel regulatory mechanisms of neurotransmitter receptor-mediated signaling has gr...
AbstractCyclin-dependent kinase 5 (Cdk5) is much more than its name implies; it plays a role in neur...
Cyclin-dependent kinase 5 (Cdk5), a member of the Cdks family, is identified to play a critical role...
Cyclin-Dependent Kinase-Like 5 (CDKL5) is a serine/threonine protein kinase important for neuronal d...
AbstractThe adult mammalian cortex is characterized by a distinct laminar structure generated throug...
Migration of neurons to their proper position underlies mammalian brain development. To remain on th...
A set of different protein kinases have been involved in tau phosphorylations, including glycogen sy...
<div><p>Protein phosphorylation is the most common post-translational modification that regulates se...
Cyclin-dependent kinase 5 is activated by small subunits, of which p35 is the most abundant. The fun...