Add to ORKGIT has been known for some time that many rheumatic and autoimmune conditions are complex in nature \ i[e[ they have both environmental and multiple genetic aetiological components [ The dissection of complex traits has previously been di.cult as existing analytical approaches \ designed for single!gene disorders \ are largely inappropriate[ It is now possible to apply new techniques to unravel complex genetic conditions and de_ne them at the DNA sequence level [ This has largely resulted from the application of advances in molecular biology \ in! formation technology and the construction of de! tailed genetic linkage maps for the human genome[ The rewards for success are potentially great and could include the identi_cation of novel therap...
License, which permits unrestricted use, distribution, and reproduction in any medium, provided the ...
Building on the spectacular success of molecular genetics in defining the biological basis of many r...
which permits unrestricted use, distribution, and reproduction in any medium, provided the original ...
International audienceRheumatology deals with many different entities among which dys/autoimmune dis...
Contains fulltext : 81633.pdf (publisher's version ) (Closed access)The field of g...
To access publisher full text version of this article. Please click on the hyperlink in Additional L...
Advances in molecular techniques and technology have unravelled many of the secrets of diseases caus...
ADVANCES in molecular biological and human cell hybridization technology significantly enhanced our ...
In the last two decades clinical rheumatological practice has been confronted with a steadily increa...
Using rheumatology as an example, the paper considers current trends in the development of medical s...
Studies of human genetics offer the potential to gain fundamental insight into the etiology of disea...
Rheumatoid arthritis is a common complex genetic disease, and, despite a significant genetic element...
Genome-wide association studies are transformative in revealing the polygenetic basis of common dise...
Rheumatoid arthritis (RA) is a chronic, systemic, inflammatory, multi-factorial disease sustained by...
International audienceThe dramatic advances made recently in human genome research are fueling consi...
License, which permits unrestricted use, distribution, and reproduction in any medium, provided the ...
Building on the spectacular success of molecular genetics in defining the biological basis of many r...
which permits unrestricted use, distribution, and reproduction in any medium, provided the original ...
International audienceRheumatology deals with many different entities among which dys/autoimmune dis...
Contains fulltext : 81633.pdf (publisher's version ) (Closed access)The field of g...
To access publisher full text version of this article. Please click on the hyperlink in Additional L...
Advances in molecular techniques and technology have unravelled many of the secrets of diseases caus...
ADVANCES in molecular biological and human cell hybridization technology significantly enhanced our ...
In the last two decades clinical rheumatological practice has been confronted with a steadily increa...
Using rheumatology as an example, the paper considers current trends in the development of medical s...
Studies of human genetics offer the potential to gain fundamental insight into the etiology of disea...
Rheumatoid arthritis is a common complex genetic disease, and, despite a significant genetic element...
Genome-wide association studies are transformative in revealing the polygenetic basis of common dise...
Rheumatoid arthritis (RA) is a chronic, systemic, inflammatory, multi-factorial disease sustained by...
International audienceThe dramatic advances made recently in human genome research are fueling consi...
License, which permits unrestricted use, distribution, and reproduction in any medium, provided the ...
Building on the spectacular success of molecular genetics in defining the biological basis of many r...
which permits unrestricted use, distribution, and reproduction in any medium, provided the original ...