Add to ORKGEndometrial cancer is the most common cancer in women with Lynch syndrome. The identification of individuals with Lynch syndrome is desirable because they can benefit from increased cancer surveillance. The purpose of this study was to determine the feasibility and desirability of mole-cular screening for Lynch syndrome in all endometrial cancer patients. Unselected endometrial cancer patients (N = 543) were studied. All tumors underwent microsatel-lite instability (MSI) testing. Patients with MSI-positive tumors underwent testing for germ line mutations in MLH1, MSH2, MSH6, and PMS2. Of 543 tumors studied, 118 (21.7%) were MSI positive (98 of 118 MSI high and 20 of 118 MSI low). All 118 patients with MSI-positive tumors had mutation testin...
A subset of women with uterine cancer exhibiting defective mismatch repair (MMR) proteins and micros...
Objective Women with Lynch syndrome have a risk up to 40-60% of developing endometrial cancer, which...
Background: Standard screening of endometrial cancer (EC) for Lynch syndrome (LS) is gaining tractio...
Lynch syndrome (LS) is a hereditary condition that increases the risk for endometrial and other canc...
Endometrial cancer is the first malignancy in 50 % of women with Lynch syndrome, an autosomal domina...
Age younger than 50 years at the time of colon cancer diagnosis is often used as a screening criteri...
Background: Lynch syndrome (LS) is a hereditary condition that increases the risk for endometrial an...
Objective. Lynch syndrome (LS) is a hereditary syndrome that predisposes to multiple malignancies in...
Lynch syndrome (LS) is an inherited disorder caused by a germline mutation in the DNA mismatch repai...
Purpose Current guidelines for Lynch syndrome detection in endometrial cancer (EC) patients rely eit...
ObjectiveLynch syndrome is the most common cause of inherited endometrial cancer, attributable to ge...
Background Endometrial carcinoma represents a sentinel cancer for Lynch syndrome (LS) identification...
BackgroundLynch syndrome (LS) predisposes to endometrial cancer (EC), colorectal cancer, and other c...
Endometrial cancer is the most common gynecologic malignancy in Canada with increasing rates of both...
Lynch syndrome is an autosomal dominant cancer-susceptibility disorder caused by mutations in DNA mi...
A subset of women with uterine cancer exhibiting defective mismatch repair (MMR) proteins and micros...
Objective Women with Lynch syndrome have a risk up to 40-60% of developing endometrial cancer, which...
Background: Standard screening of endometrial cancer (EC) for Lynch syndrome (LS) is gaining tractio...
Lynch syndrome (LS) is a hereditary condition that increases the risk for endometrial and other canc...
Endometrial cancer is the first malignancy in 50 % of women with Lynch syndrome, an autosomal domina...
Age younger than 50 years at the time of colon cancer diagnosis is often used as a screening criteri...
Background: Lynch syndrome (LS) is a hereditary condition that increases the risk for endometrial an...
Objective. Lynch syndrome (LS) is a hereditary syndrome that predisposes to multiple malignancies in...
Lynch syndrome (LS) is an inherited disorder caused by a germline mutation in the DNA mismatch repai...
Purpose Current guidelines for Lynch syndrome detection in endometrial cancer (EC) patients rely eit...
ObjectiveLynch syndrome is the most common cause of inherited endometrial cancer, attributable to ge...
Background Endometrial carcinoma represents a sentinel cancer for Lynch syndrome (LS) identification...
BackgroundLynch syndrome (LS) predisposes to endometrial cancer (EC), colorectal cancer, and other c...
Endometrial cancer is the most common gynecologic malignancy in Canada with increasing rates of both...
Lynch syndrome is an autosomal dominant cancer-susceptibility disorder caused by mutations in DNA mi...
A subset of women with uterine cancer exhibiting defective mismatch repair (MMR) proteins and micros...
Objective Women with Lynch syndrome have a risk up to 40-60% of developing endometrial cancer, which...
Background: Standard screening of endometrial cancer (EC) for Lynch syndrome (LS) is gaining tractio...