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Post-traumatic stress disorder (PTSD) affects regions that support autobiographical memory (AM) tive during negative emotional tasks in PTSD patients and the level of activity here is associated with the severity of symptoms (Etkin and Wager, 2007; Shin et al., 2006). In contrast, the medial PFC, a region associated with controlled emotional processes, is often effects of emotional reactions extend beyond traumatic memories to word-cued, important but non-trauma related, and positive autobiographical memories (Rubin et al., 2008b). Thus, although PTSD diagnosis relies on a single traumatic event the impact of PTSD is more widespread across AM. Little, however, is known about the neural basis of these effects. In the present study, we investigate the neural mechanisms affected by PTSD symptoms during retrieval of a large sample of emotionally intense AMs. We employed a generic cue method tha