study examined the effects of major burn injury on the cellular distribu-tion of several PKC isoforms in adult rat hearts and examined the hypothesis that PKC plays a regulatory role in cardiomyocyte cytokine secretion. Burn trauma was given over 40 % total body surface area in Sprague-Dawley rats. An in vitro model of burn injury included addition of burn serum, 10 % by volume, to primary cardiomyocyte cultures (collagen perfusion). In vivo burn injury produced redistribution of PKC, PKC, and PKC from the cytosol (soluble) to the membrane (particulate) component of the myocardium. This activation of the PKC isoforms was evident 2 h after burn injury and progressively increased over 24 h postburn. Addition of burn serum to isolated myocyte...
Background. Early multiple organ injuries induced by severe burn predict a high mortality. Mesenchym...
Despite advances in treatment and care, burn trauma remains the fourth most common type of traumatic...
<p>Representative immunofluorescence images of myocardium with different staining targets in rats wi...
myocyte sodium accumulation after burn injury precedes the devel-opment of myocardial contractile dy...
INTRODUCTION: Cardiomyocyte sodium accumulation after burn injury precedes the development of myocar...
Severe burn profoundly affects organs both proximal and distal to the actual burn site. Cardiovascul...
Background: Autophagy plays a major role in myocardial ischemia and hypoxia injury. The present stud...
Burn trauma causes cardiac dysfunction. However, much of the underlying cellular and molecular mecha...
This thesis is concerned with the cardiovascular changes which occur in the first 90 minutes after b...
Abstract Background Cardiac dysfunction is a common complication associated with major burns. While ...
Oxidative stress plays an important role in burn-induced myocardial injury, but the cellular mechani...
Severe inflammation leads to cardiac diastolic dysfunction, an independent prognostic marker for the...
Background. Severe burn trauma leads to an immediate and strong inflammatory response inciting cardi...
<p>Three days post-injury, FACS-sorted spleen pDCs with purity >98% were activated with CpG (18–20 h...
ABSTRACT—Although the critical role of systemic inflammatory edema in the development of multiple or...
Background. Early multiple organ injuries induced by severe burn predict a high mortality. Mesenchym...
Despite advances in treatment and care, burn trauma remains the fourth most common type of traumatic...
<p>Representative immunofluorescence images of myocardium with different staining targets in rats wi...
myocyte sodium accumulation after burn injury precedes the devel-opment of myocardial contractile dy...
INTRODUCTION: Cardiomyocyte sodium accumulation after burn injury precedes the development of myocar...
Severe burn profoundly affects organs both proximal and distal to the actual burn site. Cardiovascul...
Background: Autophagy plays a major role in myocardial ischemia and hypoxia injury. The present stud...
Burn trauma causes cardiac dysfunction. However, much of the underlying cellular and molecular mecha...
This thesis is concerned with the cardiovascular changes which occur in the first 90 minutes after b...
Abstract Background Cardiac dysfunction is a common complication associated with major burns. While ...
Oxidative stress plays an important role in burn-induced myocardial injury, but the cellular mechani...
Severe inflammation leads to cardiac diastolic dysfunction, an independent prognostic marker for the...
Background. Severe burn trauma leads to an immediate and strong inflammatory response inciting cardi...
<p>Three days post-injury, FACS-sorted spleen pDCs with purity >98% were activated with CpG (18–20 h...
ABSTRACT—Although the critical role of systemic inflammatory edema in the development of multiple or...
Background. Early multiple organ injuries induced by severe burn predict a high mortality. Mesenchym...
Despite advances in treatment and care, burn trauma remains the fourth most common type of traumatic...
<p>Representative immunofluorescence images of myocardium with different staining targets in rats wi...