HODGKIN’S DISEASE 761 HODGKIN’S DISEASE. AN

A puzzling clinical picture which was first described by Hodgkin in 18321, and since then studied and clarified by many medical men and pathologists, has recently been recognized as one of the problems confront-ing the bone surgeons. The peculiar hypertrophy and metaplasia of the cervical, mediastinal, and other lymph glands was at first not differentiated from the enlargement of these glands in lymphosarcoma, tuberculosis, and the leucaemias. Later, cases presenting symptoms of intermittent fever, anaemia, and enlargement of the spleen and lymph glands, coupled with degeneration of the hemopoietic structures and appearance of Dorothy Reed cells and eosinophils, were grouped under the name lymphogranu-loma. This disease was variously thought to be due to a specific bacillus, the tubercle bacillus, or to a neoplasm. In the exhaustive investigation of cases, the osseous system was at first only casually examined. Hyperplasia and degeneration of the bone marrow and thinning of the cortex were noted as a part of the hemopoieti