High-throughput screening (HTS) is an efficient technology for drug discovery. It allows for screening of more than 100,000 compounds a day per screen and requires effective procedures for quality control. The authors have developed a method for evaluating a background surface of an HTS assay; it can be used to correct raw HTS data. This correction is necessary to take into account systematic errors that may affect the procedure of hit selection. The described method allows one to analyze ex-perimental HTS data and determine trends and local fluctuations of the corresponding background surfaces. For an assay with a large number of plates, the deviations of the background surface from a plane are caused by systematic errors. Their influ-ence...
High-Throughput Screening (HTS) data in its entirety is valuable raw material for the drug-discovery...
主要介绍了高通量筛选技术(HTS,HighThroughputScreening)的原理,包括非细胞相筛选、细胞相筛选和生物表型筛选及其在生命科学和药学领域中的应用以及高通量筛选技术的发展趋势。Thi...
A review. A review on high throughput screening (HTS) strategies for lead discovery. Topics covered ...
Significant efforts have been made recently to improve data throughput and data quality in screening...
High-throughput screening (HTS) is the result of a concerted effort of chemistry, biology, informati...
The correction or removal of signal errors in high throughput screening (HTS) data is critical to th...
High Throughput Screening (HTS) is an effective means to determine the chemical compounds which are ...
Despite a large body of references on assay development, assay optimization, strategies, and methodo...
2015-01-26High-throughput screening (HTS) for drug discovery is a large-scale hierarchical process i...
Despite a large body of references on assay development, assay optimization, strategies, and methodo...
High throughput screening (HTS) assesses compound libraries for “activity” using target assays. A su...
High-throughput screening (HTS) is a well established process for lead discovery in Pharma and Biote...
AbstractThe pharmaceutical industry is presently suffering difficult times due to low productivity o...
We describe the nature and goals of high-throughput screening experiments, focusing on the challenge...
We describe the nature and goals of high-throughput screening experiments, focusing on the challenge...
High-Throughput Screening (HTS) data in its entirety is valuable raw material for the drug-discovery...
主要介绍了高通量筛选技术(HTS,HighThroughputScreening)的原理,包括非细胞相筛选、细胞相筛选和生物表型筛选及其在生命科学和药学领域中的应用以及高通量筛选技术的发展趋势。Thi...
A review. A review on high throughput screening (HTS) strategies for lead discovery. Topics covered ...
Significant efforts have been made recently to improve data throughput and data quality in screening...
High-throughput screening (HTS) is the result of a concerted effort of chemistry, biology, informati...
The correction or removal of signal errors in high throughput screening (HTS) data is critical to th...
High Throughput Screening (HTS) is an effective means to determine the chemical compounds which are ...
Despite a large body of references on assay development, assay optimization, strategies, and methodo...
2015-01-26High-throughput screening (HTS) for drug discovery is a large-scale hierarchical process i...
Despite a large body of references on assay development, assay optimization, strategies, and methodo...
High throughput screening (HTS) assesses compound libraries for “activity” using target assays. A su...
High-throughput screening (HTS) is a well established process for lead discovery in Pharma and Biote...
AbstractThe pharmaceutical industry is presently suffering difficult times due to low productivity o...
We describe the nature and goals of high-throughput screening experiments, focusing on the challenge...
We describe the nature and goals of high-throughput screening experiments, focusing on the challenge...
High-Throughput Screening (HTS) data in its entirety is valuable raw material for the drug-discovery...
主要介绍了高通量筛选技术(HTS,HighThroughputScreening)的原理,包括非细胞相筛选、细胞相筛选和生物表型筛选及其在生命科学和药学领域中的应用以及高通量筛选技术的发展趋势。Thi...
A review. A review on high throughput screening (HTS) strategies for lead discovery. Topics covered ...