Add to ORKGABSTRACT: The limited proliferative potential of the cultured human diploid fibroblast is now well established. A number of biological correlates suggest that this culture system is a model for the study of aging at the cellular level. The mechanism(s) that causes the loss of proliferative activity is unknown; the results of some recent studies indicate that specific genes may play a pivotal role in cellular aging in vitro. The extent to which changes in proliferative functions are causally related to aging in vivo is currently under investigation. KEY WORDS: diploid fibroblast, cellular aging, cell cycle, cell fusion. I
Half a century is fast approaching since Hayflick and colleagues formally described the limited abil...
It is the purpose of this article to show that, under very general assumptions, the observed senesce...
The influence of ionising radiations on ageing is still controversial. Since Hayflick established th...
Diploid cells in culture have a limited proliferative life span which is thought to be a manifestati...
Fibroblasts have been used since the 1960s as a cell culture model for organismal aging. Fibroblast ...
Cultured diploid human fibroblasts have a limited proliferative life span. The work presented here t...
The characteristic limited reproductive life-span of normal human fibroblasts in culture is due to a...
Cultured normal human and animal cells are predestined to undergo irreversible functional decrements...
Hayflick and Moorhead demonstrated that diploid human fibroblasts have a limited life span when grow...
This article describes the historical background to the demonstration by Hayflick and Moorhead that ...
We examined the in vitro proliferative potential of 669 cell cultures established from skin biop-sie...
Several changes in the functional characteristics of fibronectin (FN) have been noted as cells becom...
The study of the aging process is the investigation as to how the passage of time affects cells, org...
Senescence is the last period of the life span, leading to death. It happens in all animals, with th...
We have studied aging at the cellular level by examining skin fibroblast cultures derived from skin ...
Half a century is fast approaching since Hayflick and colleagues formally described the limited abil...
It is the purpose of this article to show that, under very general assumptions, the observed senesce...
The influence of ionising radiations on ageing is still controversial. Since Hayflick established th...
Diploid cells in culture have a limited proliferative life span which is thought to be a manifestati...
Fibroblasts have been used since the 1960s as a cell culture model for organismal aging. Fibroblast ...
Cultured diploid human fibroblasts have a limited proliferative life span. The work presented here t...
The characteristic limited reproductive life-span of normal human fibroblasts in culture is due to a...
Cultured normal human and animal cells are predestined to undergo irreversible functional decrements...
Hayflick and Moorhead demonstrated that diploid human fibroblasts have a limited life span when grow...
This article describes the historical background to the demonstration by Hayflick and Moorhead that ...
We examined the in vitro proliferative potential of 669 cell cultures established from skin biop-sie...
Several changes in the functional characteristics of fibronectin (FN) have been noted as cells becom...
The study of the aging process is the investigation as to how the passage of time affects cells, org...
Senescence is the last period of the life span, leading to death. It happens in all animals, with th...
We have studied aging at the cellular level by examining skin fibroblast cultures derived from skin ...
Half a century is fast approaching since Hayflick and colleagues formally described the limited abil...
It is the purpose of this article to show that, under very general assumptions, the observed senesce...
The influence of ionising radiations on ageing is still controversial. Since Hayflick established th...