Incidental mononuclear cell infiltrate in the uvea of cynomolgus monkeys

Mononuclear cell infiltrate (MCI) in the uvea was observed in naı̈ve, untreated (control group) cynomolgus monkeys in approximately 25 % of drug safety evaluation studies. The total incidence of MCI in the choroid and the ciliary body was 29 % of 342 males and 25 % of 306 female monkeys. In the studies in which MCI was present in the ciliary body or choroid, the incidence was as high as 75%. There were no other ocular histopathologic findings in these monkeys. All monkeys were clinically healthy and the eyes were not remarkable when examined ophthalmoscopically. Keywords. Mononuclear cell infiltrate in the uvea; uveitis; choroiditis; ciliary body; choroid; iris; ocular changes in cynomolgus monkeys