Ischemia-reperfusion induced microvascular responses in LDL-receptor / mice

vascular responses in LDL-receptor 2/2 mice. Am. J. Physiol. 276 (Heart Circ. Physiol. 45): H1647–H1654, 1999.—The objective of this study was to determine whether the microvas-cular responses to ischemia and reperfusion (I/R) are altered in an animal model of atherosclerosis, the low-density lipopro-tein-receptor knockout (LDLr 2/2) mouse. Intravital video microscopy was used to monitor venular wall shear rate, leukocytes rolling velocity, the number of rolling, adherent and emigrated leukocytes, and albumin leakage in cremas-teric postcapillary venules of wild-type (B6129) and LDLr 2/2 mice exposed to 60 min of ischemia and 60 min of reperfusion. The postcapillary venules of LDLr 2/2 mice exhibited two- to threefold larger increments in the number of adherent leukocytes and a more profound albumin leakage response to I/R than venules in wild-type mice. The exagger