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Alzheimer’s disease (AD) is the most com-mon form of dementia, affecting approxi-mately 30 % of those aged over 85 years [1]. AD is classified as a neurodegenerative dis-ease, impacting on brain integrity and func-tioning, resulting in a progressive deteriora-tion of cognitive capabilities [2]. Moreover, since there is currently no treatment to cure or even slow down the rate of neurodegen-eration, AD significantly decreases life qual-ity and expectancy of those suffering from it. Whereas in familial AD a genetic pre-disposition leads to the disease, no obvious inheritance pattern is observed in the far more common sporadic variant. Recent wor