Evaluation of a new reagent for anti-Cytomegalovirus and anti-Epstein-Barr virus immunoglobulin

The Enzygnost alpha method was tested against the complement fixation test and anti-VCA immunofluo-rescence to determine the respective titers of anti-cytomegalovirus and anti-Epstein-Barr virus immunoglob-ulin G antibodies. For cytomegalovirus, the Enzygnost results showed 97.99%o agreement with the readings obtained by the alternative method, with l100 sensitivity and 93.7 % specificity. For Epstein-Barr virus, Enzygnost showed 97.71 % agreement, l10o sensitivity, and 91.11 % specificity. A herpesvirus can be detected by the presence of antibodies that reflect the condition of the patient as well as the response of his immune system. Immunosuppressed subjects are more susceptible to herpesvirus infection and do not respond well (3, 7, 10, 12, 15). Because the introduction of new serological methods should be accompanied by antibody evaluation, espe-cially in the case of immunosuppressed and immunocompro-mised populations, we assessed the advantages of a new enzyme-linked immunosorbent assay (ELISA) method that determines the titers of anti-cytomegalovirus (CMV) an