Effects of Copaiba Oil on Cyclophosphamide- Induced Teratogenesis in Mice

Cyclophosphamide is an anti-neoplastic chemotherapy drug which, when administered to animals during the gestational period, provokes visceral, skeletal and external malformations. Copaiba oil obtained from Copaifera L. genus is traditionally used in popular medicine for its anti-inflamma-tory and antimicrobial activities. However, the effect of copaiba oil onteratogenesis remains un-known. This study aimed to investigate the possible protector effects of copaiba oil on the model of teratogenesis induced by cyclophosphamide in mice. Pregnant female Swiss mice were divided into 8 groups (n = 15). Three groups received copaiba oil, via gavage, in the following doses: 0.3 mL∙Kg−1, 0.6 mL∙Kg−1 and 0.9 mL∙Kg−1 (b.w.), associated to phosphate-buffered saline (PBS), intra-peritoneal (i.p.). The negative control group received medium chain triglyceride (MCT) and PBS. Th