The pharmacokinetics and tissue penetration of teicoplanin

The pharmacokinetics of teicoplanin were studied following a 440 mg intravenous dose in six male volunteers. The levels of the compound were measured in serum, blister fluid and urine. The mean serum level 0-5 h after injection was 44-6 mg/1 falling to 3-6 mg/1 at 49 h. The elimination half-life of teicoplanin from serum was 34-2 h and the apparent distribution half-life 1-5 h. Penetration into blister fluid was moderately fast, the mean maximum concentration (14-8 mg/1) occurring at 2-7 h, and the mean percentage penetration being 77-4%. Urinary recovery of the drug was 48-3 % by 96 h