Aerobic glycolysis is an important feature of cancer cells. In recent years, lactate dehydrogenase A (LDH-A) is emerging as a novel therapeutic target for cancer treatment. Seeking LDH-A inhibitors from natural resources has been paid much attention for drug discovery. Spatholobus suberectus (SS) is a common herbal medicine used in China for treating blood-stasis related diseases such as cancer. This study aims to explore the potential medicinal application of SS for LDH-A inhibition on breast cancer and to determine its bioactive compounds. We found that SS manifested apoptosis-inducing, cell cycle arresting and anti-LDH-A activities in both estrogen-dependent human MCF-7 cells and estrogen-independent MDA-MB-231 cell. Oral herbal extracts...
none4noIn the attempt of developing innovative anticancer treatments, growing interest has recently ...
Cancer is a metabolic disease in which abnormally proliferating cancer cells rewire metabolic pathwa...
LDH-A, as the critical enzyme accounting for the transformation from pyruvate into lactate, has been...
Aerobic glycolysis is an important feature of cancer cells. In recent years, lactate dehydrogenase A...
Aerobic glycolysis is an important feature of cancer cells. In recent years, lactate dehydrogenase A...
Aerobic glycolysis is an important feature of cancer cells. In recent years, lactate dehydrogenase A...
Although clinical outcomes of some cancer have been greatly improved by advancements made in surgery...
Aims: Lactate dehydrogenase (LDH)-A is highly expressed in diverse human malignant tumors, parallel ...
In recent years, small molecule inhibition of LDHA (Lactate Dehydrogenase A) has evolved as an appea...
Background: Lactate dehydrogenase (LDH) plays an important role in cancer pathogenesis and enhanced ...
Lactate dehydrogenase A (LDHA) is the enzyme that converts pyruvate to lactate and oxidizes the redu...
Although Chinese herbal compounds have long been alternatively applied for cancer treatment in China...
Lactate Dehydrogenase-A (LDH-A) is up-regulated in a broad array of cancers and is associated with p...
The lactate dehydrogenase-A (LDH-A) enzyme catalyzes the interconversion of pyruvate and lactate, is...
A characteristic feature of aggressive malignancy is the overexpression of lactic acid dehydrogenase...
none4noIn the attempt of developing innovative anticancer treatments, growing interest has recently ...
Cancer is a metabolic disease in which abnormally proliferating cancer cells rewire metabolic pathwa...
LDH-A, as the critical enzyme accounting for the transformation from pyruvate into lactate, has been...
Aerobic glycolysis is an important feature of cancer cells. In recent years, lactate dehydrogenase A...
Aerobic glycolysis is an important feature of cancer cells. In recent years, lactate dehydrogenase A...
Aerobic glycolysis is an important feature of cancer cells. In recent years, lactate dehydrogenase A...
Although clinical outcomes of some cancer have been greatly improved by advancements made in surgery...
Aims: Lactate dehydrogenase (LDH)-A is highly expressed in diverse human malignant tumors, parallel ...
In recent years, small molecule inhibition of LDHA (Lactate Dehydrogenase A) has evolved as an appea...
Background: Lactate dehydrogenase (LDH) plays an important role in cancer pathogenesis and enhanced ...
Lactate dehydrogenase A (LDHA) is the enzyme that converts pyruvate to lactate and oxidizes the redu...
Although Chinese herbal compounds have long been alternatively applied for cancer treatment in China...
Lactate Dehydrogenase-A (LDH-A) is up-regulated in a broad array of cancers and is associated with p...
The lactate dehydrogenase-A (LDH-A) enzyme catalyzes the interconversion of pyruvate and lactate, is...
A characteristic feature of aggressive malignancy is the overexpression of lactic acid dehydrogenase...
none4noIn the attempt of developing innovative anticancer treatments, growing interest has recently ...
Cancer is a metabolic disease in which abnormally proliferating cancer cells rewire metabolic pathwa...
LDH-A, as the critical enzyme accounting for the transformation from pyruvate into lactate, has been...