Add to ORKGMyc proteins are often deregulated in human brain tumors, especially in embryonal tumors that affect children. Many observations have shown how alterations of these pleiotropic Myc transcription factors provide initiation, maintenance, or progression of tumors. This review will focus on the role of Myc family members (particularly c-myc and Mycn) in tumors like medulloblastoma and glioma and will further discuss how to target stabilization of these proteins for future brain tumor therapies
Despite intensive research, the mechanisms by which deregulation of myc gene expression contributes ...
Medulloblastomas are the most frequent malignant childhood brain tumors, arising in the posterior fo...
Neuroblastoma is the first neurogenic-extracranial solid cancer occurring in infancy and childhood. ...
Myc proteins are often deregulated in human brain tumors, especially in embryonal tumors that affect...
Misregulation of MYC genes, causing MYC overexpression or protein stabilization, is frequently found...
Brain tumors are the second most common group of childhood cancers, accounting for about 20%–25% of ...
Brain tumors are responsible for high morbidity and mortality worldwide. Several fac-tors such as th...
Myc family genes are often deregulated in embryonal tumors of childhood including medulloblastoma an...
Since its discovery as an oncogene carried by the avian acute leukemia virus MC29 in myelocytomatosi...
The constitutive and dysregulated expression of the transcription factor MYCN has a central role in ...
MYCN is a member of the MYC family of proto-oncogenes. It encodes a transcription factor, MYCN, invo...
The MYC family plays essential roles during brain development and their oncogenic deregulation is im...
The MYC family of transcriptional regulators play significant roles in animal development, including...
Brain tumors are the leading cause of cancer-related deaths in children, and medulloblastoma is the ...
Neuroblastoma, the most common extracranial solid tumor of childhood, is thought to originate from u...
Despite intensive research, the mechanisms by which deregulation of myc gene expression contributes ...
Medulloblastomas are the most frequent malignant childhood brain tumors, arising in the posterior fo...
Neuroblastoma is the first neurogenic-extracranial solid cancer occurring in infancy and childhood. ...
Myc proteins are often deregulated in human brain tumors, especially in embryonal tumors that affect...
Misregulation of MYC genes, causing MYC overexpression or protein stabilization, is frequently found...
Brain tumors are the second most common group of childhood cancers, accounting for about 20%–25% of ...
Brain tumors are responsible for high morbidity and mortality worldwide. Several fac-tors such as th...
Myc family genes are often deregulated in embryonal tumors of childhood including medulloblastoma an...
Since its discovery as an oncogene carried by the avian acute leukemia virus MC29 in myelocytomatosi...
The constitutive and dysregulated expression of the transcription factor MYCN has a central role in ...
MYCN is a member of the MYC family of proto-oncogenes. It encodes a transcription factor, MYCN, invo...
The MYC family plays essential roles during brain development and their oncogenic deregulation is im...
The MYC family of transcriptional regulators play significant roles in animal development, including...
Brain tumors are the leading cause of cancer-related deaths in children, and medulloblastoma is the ...
Neuroblastoma, the most common extracranial solid tumor of childhood, is thought to originate from u...
Despite intensive research, the mechanisms by which deregulation of myc gene expression contributes ...
Medulloblastomas are the most frequent malignant childhood brain tumors, arising in the posterior fo...
Neuroblastoma is the first neurogenic-extracranial solid cancer occurring in infancy and childhood. ...