Behavioral Alterations of Ethanol on Lithium Treated Methylphenidate Induced Mania-Like Phenotype and Corticosterone Induced Depression-Like Phenotype in Swiss Albino Mice

The present study designed to evaluate the behavioral alterations of ethanol and also to compare the effect of ethanol in the manic and depressive-like behavior mice after treated with lithium chloride, when measured by actophotometer test, elevated plus maze test (EPM) and tail suspension test (TST). Male Swiss albino mice (n=72) weighing 25-30g were randomly divided into twelve groups (n=6/group). Repeated administration of MPD (2.0 mg/kg) on a 10-day, mice elicited locomotor sensitization as demonstrated by the increased in motor activities in the actophotometer test. However, LiCl (50 mg/kg) + EtOH (2.0 g/kg) groups subsequently treated in methylphenidate sensitization mice shows increased in locomotor activity. Repeated administration of CORT (20 mg/kg, i.p.) on a 16-day, mice elicited depressive-like behavior as demonstrated by the obvious increased in immobility time in the tail suspension test. However, LiCl (50 mg/kg) + EtOH (2.0 g/kg) subsequently treated in depressive-like behavior mice shows increased with immobility duration. The anxiolytic effect was potentiated by EtOH showing greater number of entries into the open arm in EPM. In contrast, LiCl failed to produce anti-anxiety like effect synergistic with EtOH exhibit increased in closed arm entries. Based on the behavioral assessment we suggested that ethanol attenuates the lithium treatment in manic and depressive-like behavior mice