ESTIMATED EXPOSURE TO PHTHALATES IN COSMETICS AND RISK ASSESSMENT

Some phthalates such as di(2-ethylhexyl) phthalate (DEHP) and dibutyl phthalate (DBP) and their metabolites are suspected of producing teratogenic or endocrine-disrupting effects. To predict possible human exposure to phthalates in cosmetics, the levels of DEHP, diethyl phtha-late (DEP), DBP, and butylbenzyl phthalate (BBP) were determined by high-performance liquid chromatography (HPLC) in 102 branded hair sprays, perfumes, deodorants, and nail polishes. DBP was detected in 19 of the 21 nail polishes and in 11 of the 42 perfumes, and DEP was detected in 24 of the 42 perfumes and 2 of the 8 deodorants. Median exposure levels to phthalates in cosmetics by dermal absorption were estimated to be 0.0006 µg/kg body weight (bw)/d for DEHP, 0.6 µg/kg bw/d for DEP, and 0.103 µg/kg bw/d for DBP. Furthermore, if phthalates in cosmetics were assumed to be absorbed exclusively via 100 % inhalation, the median daily exposure levels to phthalates in cosmetics were estimated to be 0.026 µg/kg bw/d for DEHP, 81.471 µg/kg bw/d for DEP, and 22.917 µg/kg bw/d for DBP, which are far lower than the regulation levels set buy the Scientific Committee on Toxicity, Ecotoxicity, and th