Summary

The human genome is tightly folded to fit within the restricted space of the nucleus. One of the key goals in understanding the folding principles of DNA is to unravel the mysteries of how functional elements that are separated from each other are brought together. Long-range interactions between folded segments of chromosomes form complex three-dimensional networks and are fundamental in controlling gene expression. These long-range interactions have been observed using chromosome conformation capture (3C). This Hi-C data contains a wealth of information on the nearest-neighbor influence on the deviation of the DNA axis that can be modeled theoretically. We have developed a tool using WebGL to visualize the modeled structures. Using WebGL to create a tool to visualize 3D models of DNA • WebGL is a JavaScript application for rendering graphics. It is growing popularity and increasing support among web developers, made it an ideal choice for the development of a web based tool. It is also backed by Google and due to the nature of applications it is becoming very popular in an academic setting. WebG