Add to ORKGA clear pathologic hallmark like that identified in sporadic Parkinson’s disease (PD) is lacking in many of the monogenic causes of PD. In leucine-rich repeat kinase 2 (LRRK2) mutations (PARK8), alpha-synu-clein pathology in the form of Lewy bodies (LBs) is frequently, but not consistently, observed. Other path-ologies reported in LRRK2 cases include tau inclu-sions of the Alzheimer, progressive supranuclear palsy, and frontotemporal lobar degeneration types, and TAR DNA-binding protein 43 (TDP-43) inclusions.1 There has been only a single report of a compound heterozygous, phosphatase and tensin homolog (PTEN)-induced, putative kinase 1 (PINK1; PARK6) patient coming to autopsy.2 That patient presented with asymmetrical rigidity at age 31 y...
Mutations in LRRK2 represent the most common causes of Parkinson's disease (PD) identified to date, ...
PD (Parkinson’s disease) is an aetiologically heterogeneous disorder characterized by a clinical phe...
Mutations in seven genes are robustly associated with autosomal dominant (SNCA, LRRK2, EIF4G1, VPS35...
IMPORTANCE: Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of genetic P...
Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of genetic Parkinson dis...
Importance: Mutations in the gene encoding parkin (PARK2) are the most common cause of autosomal rec...
Importance: Mutations in the gene encoding parkin (PARK2) are the most common cause of autosomal rec...
AbstractWe have previously linked families with autosomal-dominant, late-onset parkinsonism to chrom...
Autosomal recessive-juvenile parkinsonism (AR-JP) is one of the most common forms of familial Parkin...
AbstractLeucine-rich repeat kinase 2 (LRRK2) mutation is the most common cause of genetic-related pa...
Leucine-Rich Repeat Kinase 2 (LRRK2) gene mutations are the most common known cause of Parkinson's d...
The c.4309A>C mutation in the LRRK2 gene (LRRK2 p.N1437H) has recently been reported as the seventh ...
AbstractParkinson's disease (PD) is a neurodegenerative disease characterized by the selective demis...
Mutations of the parkin gene on chromosome 6 cause autosomal recessive, early onset parkinsonism. Th...
Parkinson’s disease (PD) is the most common age-related neurodegenerative movement disorder that aff...
Mutations in LRRK2 represent the most common causes of Parkinson's disease (PD) identified to date, ...
PD (Parkinson’s disease) is an aetiologically heterogeneous disorder characterized by a clinical phe...
Mutations in seven genes are robustly associated with autosomal dominant (SNCA, LRRK2, EIF4G1, VPS35...
IMPORTANCE: Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of genetic P...
Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of genetic Parkinson dis...
Importance: Mutations in the gene encoding parkin (PARK2) are the most common cause of autosomal rec...
Importance: Mutations in the gene encoding parkin (PARK2) are the most common cause of autosomal rec...
AbstractWe have previously linked families with autosomal-dominant, late-onset parkinsonism to chrom...
Autosomal recessive-juvenile parkinsonism (AR-JP) is one of the most common forms of familial Parkin...
AbstractLeucine-rich repeat kinase 2 (LRRK2) mutation is the most common cause of genetic-related pa...
Leucine-Rich Repeat Kinase 2 (LRRK2) gene mutations are the most common known cause of Parkinson's d...
The c.4309A>C mutation in the LRRK2 gene (LRRK2 p.N1437H) has recently been reported as the seventh ...
AbstractParkinson's disease (PD) is a neurodegenerative disease characterized by the selective demis...
Mutations of the parkin gene on chromosome 6 cause autosomal recessive, early onset parkinsonism. Th...
Parkinson’s disease (PD) is the most common age-related neurodegenerative movement disorder that aff...
Mutations in LRRK2 represent the most common causes of Parkinson's disease (PD) identified to date, ...
PD (Parkinson’s disease) is an aetiologically heterogeneous disorder characterized by a clinical phe...
Mutations in seven genes are robustly associated with autosomal dominant (SNCA, LRRK2, EIF4G1, VPS35...